Reina of the West is a western drama that chronicles the life of a black woman, Reina, who is forced to find a path of survival after her family abandons her. Finding other women with similar fates as her own, abandoned or outcast, Reina starts a ranch under the guise of a man's name but when a group of men in town get jealous of her ranch's success they devise a plan to shut down the ranch. Reina and her female ranch hands set out on a path to save their ranch but it also leads Reina down a road that forces her to face parts of her past that she hasn't truly come to terms with.