The second cycle of Indonesia's Next Top Model aired weekly on Indonesian private broadcaster NET. starting 4 November 2021. The number of contestants increased his cycle, making a total of 18 contestants. Luna Maya and Panca Makmun returned as host and resident judges, while Deddy Corbuzier and Patricia Gouw were replaced by guest judges and mentors from the first cycle, Ivan Gunawan and Ayu Gani. This cycle's prizes are cash amounting to hundreds of millions of Rupiahs, an all-new Suzuki XL7 car unit, as well as Samsung Galaxy Z Flip 3 5G which also served as the official partner for this cycle.

This cycle was filmed under strict health protocols as it was produced during the COVID-19 pandemic. While the previous cycle featured a local destination, this cycle didn't feature any local or international destination. However, the grand finalists took a trip to Pahawang Island of Lampung during the final episode