The Sisters are joyous, high in color, made up and on the spot in the struggle not just against homophobia and AIDS but also for the right of homosexuals to exist socially, to ensure HIV AIDS prevention and bring help and comfort to the sick. The film answers these questions: Who are the Sisters? What do they do? What are their actions and objectives? How do you become a Sister of Perpetual Indulgence. Who is their chosen audience? Even if the Sisters are playing a role, literally actors in the guerrilla theater of the struggle against discrimination, they are no less responsible, committed and often remarkable, individuals. Their comments and observations, simple and direct, enable them to address the broadest public.