The PFL 2 mixed martial arts event for the 2021 season of the Professional Fighters League was held on April 29, 2021. This was the second regular season event of the tournament and included fights in the Welterweight and Light heavyweight divisions. The event was to be headlined by a welterweight clash between the former UFC title contender and Bellator welterweight champion Rory MacDonald and the former UFC veteran David Michaud.

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