Play with Me Sesame is a children's television series spun off from Sesame Street, featuring Sesame Street characters such as Bert, Ernie, Grover, and Prairie Dawn. From April 1, 2002 until December 30, 2007, the show has aired on Noggin, which was rebranded as Nick Jr. in 2009. Play with Me Sesame moved to PBS Kids Sprout as of December 31, 2007, however, Sprout showed 26 new episodes, and all 52 episodes of both Seasons 1 and 2.

The first two seasons were produced for Noggin, and both Noggin seasons contained 26 episodes, respectively. The third, and final season was produced solely by Sesame Workshop for PBS Kids Sprout in 2007 with 26 episodes.