In Silica City, all media and entertainment are mostly based around video games, not just serving as entertainment, but also jobs in live streaming and lifestyle. Among members of society are Meta Runners, individuals who have replaced their limbs with cybernetic arms that allow them to boost their gaming performance.

The series tells the story of Tari, a Meta Runner who was the subject of an experiment called Project Blue, led by Dr. Sheridan, a scientist who was commissioned by TASCorp. After waking up in an abandoned lab, Tari finds herself in Silica City with amnesia. The last thing Tari can remember is a sudden accident causing an explosion in the lab.