A cast of colorful characters, be it, students, at school or adults in working life, face all sorts of strange and eccentric challenges on a daily basis:

The accident-prone Takagi keeps on hurting himself, making encounters at the school's infirmary with the sexually aggressive nurse Shitara unavoidable. Sushi, a talking cat, takes on various jobs like aspiring sushi chef, stunt cat, delinquent teacher, salesman, reporter, cat detective, explorer on Mars, ramen shop owner, and even as the Defender of Love — Sushi-Sushi Man... all of these jobs usually do not end well though. The ditzy pair Takao-san and Kobato-chan, of all things, struggle with the proper way of disposing of garbage. The Hamster of a family of four has to bear many misunderstandings in communication, starting off with having to respond to a different name from each family member...