1 vs. 100 is an Australian spin-off game show based on the American version of the same name and the original Dutch version created by Endemol. The game pits one person against 100 others for a chance to win one million dollars. The program is hosted by former Nine Network CEO and personality Eddie McGuire.

The Australian version of the show premiered on 29 January 2007 at 8:30 pm on the Nine Network and is recorded in the Melbourne Docklands Central City Studios.

The format of the Australian show is based on series 2 of the US show. The prize ladder is half the value of the US ladder, with a single million-dollar jackpot for eliminating all 100 players.

A second season of the show started airing on Friday, 6 June 2008 to 13 June 2008, but it was put on hiatus then cancelled.