The film follows intrepid reporters Nicholas Kristof and Sheryl WuDunn and actor/advocates Malin Akerman, Mia Farrow, Ronan Farrow, Jennifer Garner, Regina Hall, Ashley Judd, Blake Lively, Eva Longoria, and Alfre Woodard to Colombia, Haiti, Kenya, and throughout the United States as they uncover the harshest forms of gender-based oppression and human rights violations, as well as the effective solutions being implemented to combat them.

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