Due to a bomb scare at the General, the hospital is overrun with patients.

New doctors are introduced. Phil Kirkby (played by Andrew Clover) is eager, but tries too hard to impress. Smedley (Peter O'Brien of Neighbours fame) is the new registrar, who impresses the other doctors with his knowledge. In the same episode, he saves a patient who has a collapsed lung.

Dr. Collin is no longer a beginner and is now one of the experienced doctors. He is now married, and is often taking personal phone calls from his wife, Alison.

The hospital manager Alex Legg (from series 1) makes a brief appearance, only to be killed off from a heart attack.

Adrian DeVries (Jack Fortune) is the new consultant surgeon - he can perhaps be seen as this series' replacement for Mr. Betancourt. Incidentally, for the first time, the cameras move outside to show DeVries driving his car.