On Seibertron, once again at peace thanks to Vector Sigma, a new compound has been created called Seibertonuron which is many times stronger than Seibertonium. The Destron cassettes find out about it and Soundblaster reports to Galvatron, telling him that the new compound allow him to defeat the Cybertrons.

Meanwhile, back on Earth, the Headmasters are working out to keep up their conditioning. Galvatron sends the Predacons to retrieve the compound while the rest of the Destrons head to their new base. The Destron Headmasters and Sixshot meet with the shadowy Scorponok to discuss their next moves while the Cybertron Headmasters arrive at the Destron base. The Combaticons, Stunticons and Destron Headmasters then arrive on Seibertron with Galvatron and wreck havoc on the planet.

Fortress and the Headmasters then head to Seibertron with Rodimus, Cha, Blurr and Arcee. They manage to drive back the Destrons - Guardian beating Bruticus, Superion beating the Stunticons, and the Cybertron Head