Weinberg talks about the effectiveness of the Design Argument, both in the past and today. He also discusses the reasons that people become religious, including the varying influences of physical and biological arguments against religion. Miller connects this to a higher likelihood of biologists being non-believers than physicists, which Weinberg finds surprising.

Weinberg goes on to distinguish between harm done in the name of religion from that done by religion and states that both of these are very real and very dangerous. He goes on to discuss the difference between religious belief in America and Europe, and about how he doesn’t like the "character" of the monotheistic God. He ends by saying that science is very definitely corrosive to religious belief, and that he considers this a good thing.