Black Jack is ready to go Japan with Pinoko when is requested to go to the Sky Hospital and check on Zen Mantoku who has Phoenix Disease, by a direct request of Dr. White & Renka. Black Jack agrees in performing the operation with Dr. White. Renka secretly plots to get the Disease cure so she can win much money when she spreades Phoenix disease. One of Renka's henchmen tries to hijack the Hospital and by that Mantoku gets out of the Capsule causing the Phoenix Disease to spread among the aircraft. Now Black Jack has to face the Phoenix Disease to save Pinoko and the others lives.