This Thanksgiving the birds are calling the shots at Pol Veterinary Services when Charles adopts three turkeys that are on the run. Then when Gail and Lynn Wernette find a pair of wandering Great Danes near their home, they bring them to the clinic. Thin and in poor health, these dogs are in need of some serious TLC, but Dr. Pol and Diane have a full house. The hunt is on for homes for these gentle giants. Later, it's all hands on deck when Capone, a horse with a nasty cut on its hoof, arrives in the clinic parking lot. It's an uphill battle as Dr. Pol wrestles with Capone, and calls for help from his owners to get the horse treated. It wouldn't be Thanksgiving without a meal shared with family and friends and everyone from the clinic gather for a traditional Amish Thanksgiving meal, taking a break from the business of work to enjoy one another's company.