Martha Plimpton, Tom Bergeron, Sherri Shepherd, David Arquette - S2.E5

The celebrity panel of Martha Plimpton, David Arquette, Tom Bergeron, and Sherri Shepherd is faced with finding out whom the very first guest was on "The Oprah Winfrey Show," a contestant who lost 365 pounds by walking, a contestant who only ate Starbucks for 365 days, someone who can extract venom from snakes, and a professional butt model.