The entire cast of the film "50/50" is here for an exclusive interview! Ellen will be sitting down with the stars, JOSEPH GORDON-LEVITT and SETH ROGEN, to talk about this heartbreaking and hilarious film about a young person's struggle with cancer, based on the real-life story of Seth's close friend.

They'll be joined by the film's other stars, the incredible BRYCE DALLAS HOWARD and ANNA KENDRICK, who will talk about this amazing project and their personal projects... like the fact that Bryce is pregnant!

Then, MAROON 5 will perform their new hit, "Moves Like Jagger," which is tearing up the charts. You can't miss Wednesday!