VINCE VAUGHN and his mother SHEA VAUGHN are here to tell Ellen about Shea's new book -- which might hold the key to defeating stress and finding total well-being!

Then, for the first time ever, it's BONO! The U2 frontman and rock legend will be talking to Ellen about her new role as a Special Envoy for World AIDS Day, and the RED campaign.

And, she's George Clooney's newest co-star and there's already major Oscar buzz about this young star's performance. SHAILENE WOODLEY is here to discuss her role in the new hit film, "The Descendants" -- and what it's like to have George Clooney play your dad!

Plus, it's the first day of our 12 Days of Giveaways! Zooey Deschanel's music group, SHE & HIM is here to celebrate with a performance of "Rockin' Around the Christmas Tree" from their upcoming holiday CD, "A Very She & Him Christmas." It's a jam-packed holiday on Ellen that you won't want to miss!