A distraught man (Samberg), pressed against the side of a building, threatens to jump to his death. A second man (Forte), using a bullhorn, tries to talk him out of it. After a bit of dialogue, it is revealed that the distraught man is safely on the ground and his friend is kneeling mere inches away from him. The short ends after it is revealed to be a commercial for peyote.

Peyote was written and filmed after Lettuce had aired, making it the second SNL Digital Short made by The Lonely Island. It was deemed "too similar" to Lettuce to be aired right away, however, so the group produced Lazy Sunday to showcase other aspects of their comedic range.