Various couples in the ED are at odds with each other - Terri and Jack are on the rocks following Nelson and Frank's discovery of their affair. Scott is shocked when he finds that Cate has requested a new partner. When a prison van is involved in an accident, Jessica bonds with an injured nurse, bringing her into conflict with Dan who's concerned she's getting too emotionally involved with her patient, while Von nurses a murderer who must face his mortality, leading to tragic and shocking revelations for all involved.