The series begins with the four Sorelli sisters in the midst of their very complicated lives together. Oldest sister Ginnie, a high powered attorney is having difficulty on telling her husband that they are having a baby. Ann (guest star Laura San Giacomo) is dealing with the fact that her longterm relationship with her boyfriend Danny (guest star Jon Hamm) may be over. Marjee is in a rut on finding a restaurant to host a Pug Dog Benefit featuring Jillian Barbaree that will have live dogs. Also, college student Rose is having a hard time telling the family that she has switched college majors from Pre-Med to the Experimental Theatre Ring.

While all the sisters lives are in a rut they also have to plan their father's engagement party as he is remarrying to a woman that they don't particularly care for.