Honey's Sit-N-Eat (Philadelphia, PA), Louie & the Red Head Lady (Mandeville, LA), Picabu Neighborhood Bistro (Spokane, WA)

This trip Guy's pulling up for some one-of-a-kind meals. In Spokane, Washington, a joint in a shopping center slathering burgers with a remoulade they call "Goo." In Philadelphia, Pennsylvania, a Southern/Jewish fusion restaurant serving Bubby's brisket with beans and rice. And in Mandeville, Louisiana, a family-style favorite putting a Cajun spin on Oysters Rockefeller.