Taco Taco (San Antonio, Tex.); Whitner's Barbecue (Virginia Beach, Va.); DMK Burger Bar (Chicago, Ill.).

This trip, Guy's goin' for meat in the middle. In San Antonio, a Greek owner hand rolls tortillas for Mexican favorites like fried puffy tacos stuffed with chicken. In Virginia Beach, a real deal BBQ joint serves up burnt ends on a bun with homemade rub and sauce. And in Chicago, a gourmet restaurant vet brings fine dining to the bar with innovative burgers like bison with blueberry BBQ sauce.