An extremely nervous Simon comes home to Glenoak to await the results of his STD test. Eric counsels a woman (guest-star Erika Alexander) who is caring for her two daughters (guest-stars Bree' Anna Banks and Brandi Vanice) with sickle cell anemia and whose absentee father (guest-star Victor Love) is hoping to take them back with him to Memphis for treatment at St. Jude Children's Research Hospital.

Meanwhile, Ruthie's ex-boyfriend, Peter (guest-star Scotty Leavenworth), pays her a surprise visit, which creates problems with her current boyfriend, Vincent (guest-star Thomas Dekker). Lucy and Kevin disagree over who should care for Savannah when Lucy returns to work. Lastly, Martin misses an important call from his father in Iraq while sneaking out of the house to be with his girlfriend.