The second series started on 30 March 2013. On 13 November 2012, it was confirmed that all four coaches from last year will return. The show's Blind Auditions will move to MediaCityUK in Salford, Manchester. It was also confirmed that the live show format will be tweaked for this series, which include the cutback from six live shows in the first series to only three live shows, and the pre-recorded results show has also been dropped, with the results given on the same night as the performances. On 28 February 2013, four ten-second teaser trailers were posted to the show's official website and YouTube page.

This was the final series to feature Jessie J and Danny O'Donoghue as coaches, and Holly Willoughby and Reggie Yates as hosts.