After giving birth to the Chōjin, Akemi reawakens in a hospital, along with Jyaku, who had barely survived a recent confrontation with the Chōjin (whose form constantly mutates between male and female). Destroyer God Tatsuo also reappears (after supposedly being killed by Kyō-Ō in Urotsukidoji: Return of the Overfiend) and continues his ravaging of Earth. Still in love with Tatsuo, Akemi runs out to find him.

Meanwhile, Jyaku is confronted by some of the Chōjin's new 'children', and engages them in battle. However, his efforts prove almost futile, as they are constantly regenerated by the Chojin. Akemi eventually finds Tatsuo, still in his God form, and pleads with him. He clutches her in his hand (similarly to the end of the first episode) and prepares to kill her. However, she is rescued at the last minute by Jyaku, although she condemns him for doing so.