The sixth and final cycle of Asia's Next Top Model premiered on 22 August 2018. Filming for the cycle took place in Bangkok, Thailand. Cindy Bishop and Yu Tsai both returned as judges for the panel, while Monika Sta. Maria from Cycle 3 as well as Shikin Gomez and Nguyen Minh Tu from Cycle 5 made appearances as Model Mentors throughout the cycle.

The cycle featured 14 contestants with the prize package for this cycle included a Subaru XV, a cover and fashion spread in Harper's Bazaar Thailand, a featured avatar in the new America's Next Top Model Mobile Game, and a modeling contract with Storm Model Management in London.