The sixth season of SupermodelMe aired on 11 October 2021 after a 7-year hiatus, with the shooting location being moved back to Singapore. The previous judging panel was mostly replaced by the judging panel of Asia's Next Top Model, with Thai model Cindy Bishop appointed as the Host and Head Judge, and Yu Tsai appointed as the Creative Consultant. Ase Wang returned to the judging panel for the fourth time. Asia's Next Top Model alumni Dana Slosar and Monika Santa Maria were added as the Task Masters.

This season features 12 contestants, with the prizes for this season being a Subaru Ambassadorship, a cover on Harper’s BAZAAR, and a modeling contract with Storm Model Management. This season won Best Editing at the Asian Academy Creative Awards 2022.