La Blue Girl Returns (four episodes, 2001) is an anime series that continues the adventures of Miko Mido. Another original story, this time about the legendary Shikima Brain, a place rumored to bring total power over the universe. It is coveted by the insectoid ninja clan of the Mahoroba and protected by a mysterious clan, who may have a relation with Miko's previous life.

The plot begins when a race of butterfly-like demons named the Mahoroba want to enslave Miko Mido and her sister to steal the seal case that controls the Shikima. Their ultimate goal is to conquer the Shikima Brain, a legendary place of the Shikima realm which is said to confer the power to rule the universe.