La Madrastra is a Mexican telenovela. It was produced by Televisa and broadcast on Canal de las Estrellas in Mexico from 7 February 2005 through 29 July 2005. The program became an unexpected success, garnering ratings in excess of 30 points. Starring Victoria Ruffo and César Évora, who last appeared together in 2000's Abrázame muy fuerte, La madrastra tells the story of María, a woman who lost twenty years of her life after being falsely accused of murder and who returns to Mexico to exact revenge on her husband and friends who abandoned her and to see her beloved children once more.

La Madrastra is fourth in a series of remakes of the 1981 Chilean production of the same name. The program aired five nights a week, Monday through Friday, at 9 pm for 25 weeks. A follow-up special, La madrastra: años después, aired shortly after the finale on 30 July 2005.