Appointment with Adventure is a half-hour adventure/dramatic anthology television series broadcast live on CBS from 1955-1956. The program has no host. It aired at 10 p.m. EST on the Sunday evening schedule between the better known Alfred Hitchcock Presents and What's My Line? It ran opposite The Loretta Young Show on NBC and Life Begins at Eighty, a panel discussion series hosted by Jack Barry on ABC.

The series aired fifty-three episodes, having premiered on April 3, 1955, near the end of the regular 1954-1955 television season. It ran throughout the spring and summer of 1955 and began its fall run on October 2, 1955, concluding new segments on April 1, 1956. In effect, the series ran for a full year without the summer rebroadcast period standard for most programs.

Episodes centered upon wars in U.S. history as well as dramatizations from events from many places throughout the world, then and in the past. In the episode which aired on May 1, 1955, Polly Bergen, Dane Clark, and Hugh Reilly starred in "Rendezvous in Paris." Tony Randall and Jack Klugman, fifteen years prior to their television roles as Felix Unger and Oscar Madison, respectively, in ABC's The Odd Couple, appeared with Gena Rowlands, later on NBC's 87th Precinct, in the September 4, 1955, episode entitled "The Pirate's House." Randall also appeared two months earlier in the Appointment with Adventure episode "Caribbean Cruise."