In the world of Encantadia, four Sang'gres guard the gems that hold the power to maintain peace and harmony in the land. Pirena is the keeper of the Gem of Fire, Amihan is the keeper of the Gem of Air, Alena is the keeper of the Gem of Water, and Danaya is the keeper of the Gem of Earth.

The sisters' strong bond is broken when Pirena discovers that she is unlike them. Their mother, Ynang Reyna Minea, is afraid of her desire to become the ruler of Encantadia and it is this imagined betrayal that leads her to become susceptible to the manipulations of Hagorn, King of Hathoria. This sets into motion an epic journey for the Sang'gres to discover the importance of family, love, and forgiveness.